Collaborative Biological Studies
At the heart of our research is the bioactivity of our natural product targets. To this end, we work closely with our collaborators (see here for more information) to idently the cellular targets of these molecules. Additionally, we can use our concept of "Bioactivity-Guided Retrosynthesis" to generate synthetic intermediates that can be assayed in order to broaden the SAR scope, and possibly generate molecules that are simpler and with similar or higher bioactivity than the natural product. Current projects include:
- Palau'amine, in collaboration with Professor Jun Liu, Johns Hopkins Universit.
- Ophiobolin A, in collaboration with Dr. Joe Taube (Baylor University) and Professor Alex Kornienko (Texas State University).
- Salarin C, in collaboration with Professor Jun Liu, Johns Hopkins University.
- Agelastatin A, in collaboration with Dr. Joe Taube, Baylor University.
- Oxazolomycin A, in collaboration with Professor Stephan Sieber, Technical University of Munich.